abstract：:Diet has been shown to modulate M(1)dG adduct, a biomarker of oxidative stress and lipid peroxidation. Thus, we analysed the association between diet and M(1)dG in 120 controls and 67 Map Ta Phut industrial estate workers in Rayong, Thailand, to evaluate the influence of fruit and vegetables, and fried and charcoal-gr...

journal_title：Free radical research

authors： Peluso M,Munnia A,Piro S,Jedpiyawongse A,Sangrajrang S,Giese RW,Ceppi M,Boffetta P,Srivatanakul P

更新日期：2012-01-01 00:00:00

abstract：:The intestinal tract, known for its capability for self-renew, represents the first barrier of defence between the organism and its luminal environment. The thiol/disulfide redox systems comprising the glutathione/glutathione disulfide (GSH/GSSG), cysteine/cystine (Cys/CySS) and reduced and oxidized thioredoxin (Trx/T...

journal_title：Free radical research

authors： Circu ML,Aw TY

更新日期：2011-11-01 00:00:00

abstract：:Melatonin is an endogenous indolamine, classically known as a light/dark regulator. Besides classical functions, melatonin has also showed to have a wide range of antitumoral effects in numerous cancer experimental models. However, no definite mechanism has been described to explain the whole range of antineoplasic ef...

journal_title：Free radical research

authors： Sánchez-Sánchez AM,Martín V,García-Santos G,Rodríguez-Blanco J,Casado-Zapico S,Suarez-Garnacho S,Antolín I,Rodriguez C

更新日期：2011-11-01 00:00:00

abstract：:The NADPH oxidase (NOX) family of enzymes oxidase catalyzes the transport of electrons from NADPH to molecular oxygen and generates O(2)(•-), which is rapidly converted into H(2)O(2). We aimed to identify in hepatocytes the protein NOX complex responsible for H(2)O(2) synthesis after α(1)-adrenoceptor (α(1)-AR) stimul...

journal_title：Free radical research

authors： Diaz-Cruz A,Vilchis-Landeros MM,Guinzberg R,Villalobos-Molina R,Piña E

更新日期：2011-11-01 00:00:00

abstract：:Diabetes mellitus is a risk factor for prognosis after liver resection. In previous work, we found a pro-apoptotic state in the diabetic rat liver. In this work, this was also observed 1 hour post-partial hepatectomy (PH) and resulted in a deficient regenerative response 24 hours post-PH. Treatment with insulin and/or...

journal_title：Free radical research

authors： Francés DE,Ronco MT,Ingaramo PI,Monti JA,Pisani GB,Parody JP,Pellegrino JM,Carrillo MC,Martín-Sanz P,Carnovale CE

更新日期：2011-10-01 00:00:00

abstract：:Oxidative stress has been consistently linked to ageing-related neurodegenerative diseases. Neurodegenerative diseases are characterized by progressive dysfunction and death of neurons. Oxidative stress is associated with dysfunction of the mitochondria and endoplasmic reticulum, inducing apoptosis and protein misfold...

journal_title：Free radical research

authors： Ghosh N,Ghosh R,Mandal SC

更新日期：2011-08-01 00:00:00

abstract：:Extensive research in the past decade has revealed cancer to be a multigenic disease caused by perturbation of multiple cell signalling pathways and dysregulation of numerous gene products, all of which have been linked to inflammation. It is also becoming evident that various lifestyle factors, such as tobacco and al...

journal_title：Free radical research

authors： Sung B,Prasad S,Yadav VR,Lavasanifar A,Aggarwal BB

更新日期：2011-08-01 00:00:00

abstract：:Intracellular production of reactive oxygen species (ROS) plays an important role in the control of cell physiology. For the assessment of intracellular ROS production, a plethora of fluorescent probes is commonly used. Interestingly, chemical structures of these probes imply they could be substrates of plasma membran...

journal_title：Free radical research

authors： Procházková J,Kubala L,Kotasová H,Gudernová I,Šrámková Z,Pekarová M,Sarkadi B,Pacherník J

更新日期：2011-07-01 00:00:00

abstract：:The classical functions of p53 protein are those related to its role on DNA damage, cell growth arrest, senescence and apoptosis. For this reason it is called 'the guardian of the genome' and is considered one of the most important players in the development of cancer. However, more recently it has been show that p53 ...

journal_title：Free radical research

authors： Borrás C,Gómez-Cabrera MC,Viña J

更新日期：2011-06-01 00:00:00

abstract：:Enhanced oxidative stress partly resulting from an over-production of superoxide anion (O(2)(•-)) represents a novel and particular risk factor in chronic kidney disease (CKD) patients. This study was therefore designed to evaluate O(2)(•-) determinants in this population. O(2)(•-) production was evaluated using chemi...

journal_title：Free radical research

authors： Morena M,Patrier L,Jaussent I,Bargnoux AS,Dupuy AM,Badiou S,Leray-Moragues H,Klouche K,Canaud B,Cristol JP

更新日期：2011-06-01 00:00:00

abstract：:The bioactive flavonoid baicalein has been shown to have radioprotective activity, although the molecular mechanism is poorly understood in vivo. C57BL/6 mice were irradiated with X-rays (15 Gy) with and without baicalein treatment (5 mg/kg/day). Irradiation groups showed an increase of NF-κB-mediated inflammatory fac...

journal_title：Free radical research

authors： Lee EK,Kim JM,Choi J,Jung KJ,Kim DH,Chung SW,Ha YM,Yu BP,Chung HY

更新日期：2011-05-01 00:00:00

abstract：:To study the role of oxidative stress in hypertension and pre-hypertension, this study analysed plasma levels of reactive carbonyl species (RCS) in 1204 Chinese Han adults. Results showed a statistically significant positive correlation (p < 0.001) between blood pressure and plasma RCS levels with or without being adj...

journal_title：Free radical research

authors： Chen K,Xie F,Liu S,Li G,Chen Y,Shi W,Hu H,Liu L,Yin D

更新日期：2011-05-01 00:00:00

abstract：:Curcumin is a polyphenol derived from the plant Curcuma longa that induces apoptotic cell death in malignant cancer cell lines. It has been shown previously that mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) plays an essential role in defense against oxidative stress by supplying NADPH for antioxidan...

journal_title：Free radical research

authors： Jung KH,Park JW

更新日期：2011-04-01 00:00:00

abstract：:Stichodactyla heliantus II (St II) is a haemolytic toxin whose activity depends of the characteristics of red blood cells (RBC). Among the factors that may tune the response of the RBC to the toxin activity stand the oxidative status of the cell. This study investigates how pre-oxidation of RBC modifies St II activity...

journal_title：Free radical research

authors： Celedón G,González G,Lissi E,Cerda T,Bascuñant D,Lepeley M,Pazos F,Lanio ME,Alvarez C

更新日期：2011-04-01 00:00:00

abstract：:It has previously been reported that the globular form of adiponectin (gAd), mature adipocyte-derived cytokine, induced generation of reactive oxygen species (ROS) and nitric oxide (NO) in the murine macrophage cell line RAW 264. This study investigated whether diacylglycerol kinases (DGKs), enzymes functioning in sub...

journal_title：Free radical research

authors： Kamio N,Akifusa S,Yamashita Y

更新日期：2011-03-01 00:00:00

abstract：:Interactions between transition metal ions and polyphenols can result in complexation, redox or polymerization, but the relative importance of these reactions is unclear. The present paper reports results from the reaction of gallic acid (GA) with Cu(II) using electron paramagnetic resonance (EPR) and UV/visible spect...

journal_title：Free radical research

authors： Severino JF,Goodman BA,Reichenauer TG,Pirker KF

更新日期：2011-02-01 00:00:00

abstract：:Nitration-induced protein damage in the placenta leads to impaired blood flow and deficient feto-placental exchange in diabetic pregnancies. This work studied the effect of nitric oxide and peroxynitrite on Cu/Zn SOD activity in rat placentas and evaluated whether Cu/Zn SOD is nitrated in the placenta from diabetic ra...

journal_title：Free radical research

authors： White V,Capobianco E,Higa R,Martínez N,Sosa M,Pustovrh MC,Jawerbaum A

更新日期：2010-12-01 00:00:00

abstract：:An increasing incidence of unresponsiveness to antimonials in Leishmaniasis has led to identification of plant-derived anti-leishmanial compounds like Artemisinin. Since iron-mediated generation of free radicals sustains the anti-malarial activity of Artemisinin, this study investigated whether similar mechanisms acco...

journal_title：Free radical research

authors： Sen R,Saha P,Sarkar A,Ganguly S,Chatterjee M

更新日期：2010-11-01 00:00:00

abstract：:Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is discussed in this review. New d...

journal_title：Free radical research

authors： Negre-Salvayre A,Auge N,Ayala V,Basaga H,Boada J,Brenke R,Chapple S,Cohen G,Feher J,Grune T,Lengyel G,Mann GE,Pamplona R,Poli G,Portero-Otin M,Riahi Y,Salvayre R,Sasson S,Serrano J,Shamni O,Siems W,Siow RC,Wis

更新日期：2010-10-01 00:00:00

abstract：:Along with differentiation of mouse stromal preadipocytes OP9 into adipocytes, intracellular ROS, especially superoxide anion radicals detected by NBT reduction assay, were found to appreciably increase, mainly in cytoplasmic area, parallelling with increases in intracellular lipid-droplet accumulation, whereas undiff...

journal_title：Free radical research

authors： Saitoh Y,Xiao L,Mizuno H,Kato S,Aoshima H,Taira H,Kokubo K,Miwa N

更新日期：2010-09-01 00:00:00

abstract：:Membrane rafts (MRs) are specialized microdomains in the cell membrane with an altered lipid composition. Upon various stimulations, MRs can be clustered to aggregate or recruit NADPH oxidase sub-units and related proteins to form MR redox signalosomes in the membrane of cells like vascular endothelial cells (ECs). Mu...

journal_title：Free radical research

authors： Zhang C,Li PL

更新日期：2010-08-01 00:00:00

abstract：:Reactive oxygen species (ROS) are critically important chemical intermediates in biological studies, due to their multiple physiologically essential functions and their often pathologically deleterious effects. Consequently, it is vital that their presence in biological samples has to be quantifiable. However, their h...

journal_title：Free radical research

authors： Chen X,Zhong Z,Xu Z,Chen L,Wang Y

更新日期：2010-06-01 00:00:00

abstract：:The effect of antioxidant supplementation on biomarkers of oxidative stress was investigated in a 6-week intervention study in 60 overweight men. The supplement contained a combination of antioxidants aiming to correspond to the antioxidant content found in a diet rich in fruit and vegetables. Placebo, single or doubl...

journal_title：Free radical research

authors： Rytter E,Johansson C,Vessby B,Sjödin A,Möller L,Akesson B,Basu S

更新日期：2010-05-01 00:00:00

abstract：:Retinal mitochondria become dysfunctional in diabetes and the production of superoxide radicals is increased; over-expression of MnSOD abrogates mitochondrial dysfunction and prevents the development of diabetic retinopathy. The mitochondrial DNA (mtDNA) is particularly prone to oxidative damage. The aim of this study...

journal_title：Free radical research

authors： Madsen-Bouterse SA,Zhong Q,Mohammad G,Ho YS,Kowluru RA

更新日期：2010-03-01 00:00:00

abstract：:Globular adiponectin (gAd) induces the generation of reactive oxygen species (ROS) and nitric oxide (NO) in the murine macrophage cell line RAW 264. This study investigated the role of the mammalian target of rapamycin (mTOR) in gAd-induced ROS and NO generation. gAd stimulation induced phosphorylation of mTOR, which ...

journal_title：Free radical research

authors： Fujimoto A,Akifusa S,Kamio N,Hirofuji T,Nonaka K,Yamashita Y

更新日期：2010-02-01 00:00:00

abstract：:The beneficial effects of hyperoxia have been noted in treatment of several diseases and pathological states. However, the excessive production of ROS under hyperoxic conditions can directly damage cellular macromolecules if the imbalance in antioxidant status exists. Cytochrome P450 (Cyp) 4a14 has an important role i...

journal_title：Free radical research

authors： Sobocanec S,Balog T,Sarić A,Sverko V,Zarković N,Gasparović AC,Zarković K,Waeg G,Macak-Safranko Z,Kusić B,Marotti T

更新日期：2010-02-01 00:00:00

abstract：:The impact of classic cardiovascular risk factors on oxidative stress status in a high-risk cardiovascular Mediterranean population of 527 subjects was estimated. Oxidative stress markers (malondialdehyde, 8-oxo-7'8'-dihydro-2'-deoxyguanosine, oxidized/reduced glutathione ratio) together with the activity of antioxida...

journal_title：Free radical research

authors： Fandos M,Corella D,Guillén M,Portolés O,Carrasco P,Iradi A,Martínez-González MA,Estruch R,Covas MI,Lamuela-Raventós RM,Michavilla MT,Cerdá C,Torregrosa R,Redón J,Chaves FF,Tormos MC,Ocete D,Sáez GT

更新日期：2009-12-01 00:00:00

abstract：:Subjecting selected peptides to in vitro analyses covering their ability to interfere with the lipid oxidation chain reaction as well as to protect proteins from direct and indirect oxidation has provided the basis for a more detailed understanding of peptide-mediated protection in biological systems. The efficiency o...

journal_title：Free radical research

authors： Jongberg S,Carlsen CU,Skibsted LH

更新日期：2009-10-01 00:00:00

abstract：:The present study has been designed and carried out to investigate the protective role of taurine (2-aminoethanesulphonic acid) against NaAsO(2) induced nephrotoxicity. Oral administration of arsenic increased the productions of ROS and RNS, enhanced lipid peroxidation, protein carbonylation and decreased intracellula...

journal_title：Free radical research

authors： Roy A,Manna P,Sil PC

更新日期：2009-10-01 00:00:00

abstract：:To examine local and systemic oxidative status of lung cancer (LC) and oxidant effects of radiotherapy (RT), this study evaluated antioxidants and markers of oxidative and nitrosative stress in bronchoalveolar lavage (BAL) fluid and in the blood of 36 LC patients and 36 non-cancer controls at baseline and during and a...

journal_title：Free radical research

authors： Crohns M,Saarelainen S,Kankaanranta H,Moilanen E,Alho H,Kellokumpu-Lehtinen P

更新日期：2009-07-01 00:00:00

abstract：:The singlet oxygen (1O2) quenching and free radical (DPPH(*), ABTS(* +) and O2(* -)) scavenging ability of three structurally-related flavonoids (7-hydroxyflavanone HF, 2',4'-dihydroxychalcone DHC and 3,7-dihydroxyflavone DHF) present in the Argentinean native shrub Zuccagnia punctata Cav. were studied in solution by ...

journal_title：Free radical research

authors： Vieyra FE,Boggetti HJ,Zampini IC,Ordoñez RM,Isla MI,Alvarez RM,De Rosso V,Mercadante AZ,Borsarelli CD

更新日期：2009-06-01 00:00:00

abstract：:The potential of free radical formation in serum of beta-thalassemia/Hb E patients receiving a single oral dose of 25 mg/kg body weight of deferiprone, a bidentate orally active iron chelator, was evaluated using EPR/spin trapping technique. In the presence of ascorbic acid and tert-butylhydroperoxide, EPR signals of ...

journal_title：Free radical research

authors： Jirasomprasert T,Morales NP,Limenta LM,Sirijaroonwong S,Yamanont P,Wilairat P,Fucharoen S,Chantharaksri U

更新日期：2009-05-01 00:00:00

abstract：:Adenosine levels are increased in stress and act as anti-oxidant and anti-inflammatory mediators by binding to 4 G-protein-coupled receptors. Using genetically modified mice lacking A(1) and A(3) adenosine receptors, treated with ip buthionine-[S,R]-sulphoximine injections to inhibit gamma-glutamylcysteine ligase, the...

journal_title：Free radical research

authors： Conte C,Grottelli S,Prudenzi E,Bellezza I,Fredholm BB,Minelli A

更新日期：2009-03-01 00:00:00

abstract：:Rabbits were fed a diet containing 1% cholesterol for 8 weeks and the levels of iron and oxidized lipids in liver analysed using atomic absorption spectroscopy and gas chromatography-mass spectrometry. A non-significant trend to an increase in iron level, but significant increases in the lipid peroxidation products, F...

journal_title：Free radical research

authors： Ong WY,Jenner AM,Pan N,Ong CN,Halliwell B

更新日期：2009-03-01 00:00:00

abstract：:The possible protective effects of resveratrol (RVT) against cardiotoxicity were investigated in Wistar albino rats treated with saline, saline+doxorubicin (DOX; 20 mg/kg) or RVT (10 mg/kg)+DOX. Blood pressure and heart rate were recorded on the 1st week and on the 7th week, while cardiomyopathy was assessed using tra...

journal_title：Free radical research

authors： Tatlidede E,Sehirli O,Velioğlu-Oğünc A,Cetinel S,Yeğen BC,Yarat A,Süleymanoğlu S,Sener G

更新日期：2009-03-01 00:00:00

abstract：:It has been observed that H9c2 cardiac cells cultured in physiologic solutions exhibit delayed cell death after repeated medium replacements, of which the cause was the relatively mild osmotic challenges during the renewal of the culture medium. Interestingly, the cell damage was associated with altered intracellular ...

journal_title：Free radical research

authors： Lee JW,Ko YE,Lee IH,Lee HK,Kim HW,Kim YH

更新日期：2009-03-01 00:00:00

abstract：:There is a correlation between oxidative stress generated by diethylnitrosamine (DEN) metabolism and liver cancer development. Quercetin is a flavonoid with anti-carcinogenic and antioxidant properties. This study demonstrates the mechanism of action for the chemopreventive effect of quercetin. A 10 mg/kg dose of quer...

journal_title：Free radical research

authors： Vásquez-Garzón VR,Arellanes-Robledo J,García-Román R,Aparicio-Rautista DI,Villa-Treviño S

更新日期：2009-02-01 00:00:00

abstract：:Adriamycin (ADR) is nephrotoxic. One component of ADR-induced nephropathy may be oxidative stress. This study used a recently developed line of transgenic mice (Nmt) on the FVB background strain, which over-express the antioxidant protein metallothionein (MT) in podocytes. Cultured podocytes from Nmt mice were resista...

journal_title：Free radical research

authors： Yang L,Zheng S,Epstein PN

更新日期：2009-02-01 00:00:00

abstract：:Oxidative modifications are a hallmark of oxidative imbalance in the brains of individuals with Alzheimer's, Parkinson's and prion diseases and their respective animal models. While the causes of oxidative stress are relatively well-documented, the effects of chronically reducing oxidative stress on cognition, patholo...

journal_title：Free radical research

authors： Siedlak SL,Casadesus G,Webber KM,Pappolla MA,Atwood CS,Smith MA,Perry G

更新日期：2009-02-01 00:00:00

abstract：:In severe COPD patients, oxidative stress, which is involved in their peripheral muscle dysfunction, increases in response to exercise. In this study, muscle oxidative stress was explored after quadriceps magnetic stimulation training. A randomized controlled study was conducted on very severe COPD patients, who under...

journal_title：Free radical research

authors： Bustamante V,Casanova J,López de Santamaría E,Mas S,Sellarés J,Gea J,Gáldiz JB,Barreiro E

更新日期：2008-11-01 00:00:00